Epilepsy is a neurologic disorder characterized by recurrent seizures. It affects millions of people worldwide, making it one of the most common neurological conditions. For many years, finding an effective treatment for epilepsy has been a challenge, with traditional medications often causing severe side effects and limited effectiveness.

What is CBD?

CBD, or cannabidiol, is a compound found in the cannabis plant. Unlike THC, the psychoactive compound in marijuana, CBD does not produce a “high” and is generally well-tolerated by individuals. Studies have shown that CBD has numerous potential therapeutic benefits, including its anticonvulsant properties.

How CBD Works in Epilepsy

Recent research has shown that CBD can interact with receptors in the brain that control neuron activity, reducing the likelihood and severity of seizures. It is believed that CBD modulates GABAergic and glutamatergic neurotransmission, which play a crucial role in epilepsy.

Additionally, CBD has been found to have anti-inflammatory and neuroprotective effects, which can help protect the brain from damage associated with seizures.

Scientific Evidence

Several clinical trials and studies have investigated the efficacy of CBD in treating epilepsy, particularly in children with Dravet syndrome and Lennox-Gastaut syndrome (LGS), two severe forms of epilepsy.

One landmark study published in The New England Journal of Medicine in 2017 found that CBD significantly reduced the frequency of seizures in children with Dravet syndrome. The study reported a 39% reduction in seizure frequency compared to 13% in the placebo group.

Similarly, another study published in The Lancet in 2018 demonstrated that CBD reduced the drop seizure frequency by 41% in patients with LGS, compared to 17% in the placebo group.

These findings, along with numerous anecdotal reports, have ignited hope for individuals suffering from treatment-resistant epilepsy.

Considerations and Side Effects

While CBD shows promise as a treatment for epilepsy, it is essential to consult with a healthcare professional before starting any new treatment. They can provide guidance on dosage, potential drug interactions, and offer insights specific to individual circumstances.

Some possible side effects of CBD include drowsiness, fatigue, changes in appetite, and dry mouth. However, these side effects tend to be minor compared to the more severe side effects associated with traditional anti-epileptic medications.


The legal status of CBD varies from country to country. In some places, CBD derived from hemp is legal, while in others, it may only be available through prescription for specific conditions such as epilepsy. It is crucial to familiarize oneself with local laws and regulations before considering CBD as a treatment option.


CBD shows great promise as a treatment for epilepsy, particularly in individuals with treatment-resistant forms of the condition. Its anticonvulsant properties, coupled with its relatively mild side effects, make it an attractive option for those seeking alternative therapies. However, as with any medical intervention, it is important to consult with a healthcare professional for proper guidance and dosage recommendations.